Characterization of a novel extended-spectrum beta-lactamase from Pseudomonas aeruginosa
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چکیده
منابع مشابه
OXA-17, a further extended-spectrum variant of OXA-10 beta-lactamase, isolated from Pseudomonas aeruginosa.
Pseudomonas aeruginosa isolates 871 and 873 were isolated at Hacettepe University Hospital in Ankara and were highly resistant to ceftazidime (MIC, 128 microg/ml). Each produced three beta-lactamases, with pIs of 5.3, 6.1, and 7.9. The beta-lactamase with a pI of 5.3 was previously shown to be PER-1 enzyme. The antibiograms of the isolates were not entirely explained by production of PER-1 enzy...
متن کاملOXA-18, a class D clavulanic acid-inhibited extended-spectrum beta-lactamase from Pseudomonas aeruginosa.
Clinical isolate Pseudomonas aeruginosa Mus showed resistance both to extended-spectrum cephalosporins and to aztreonam. We detected a typical double-disk synergy image when ceftazidime or aztreonam was placed next to a clavulanic acid disk on an agar plate. This resistance phenotype suggested the presence of an extended-spectrum beta-lactamase. Isoelectric focusing revealed that this strain pr...
متن کاملExtended Spectrum Beta Lactamases Producing Pseudomonas aeruginosa Expressing Amp C Beta-Lactamase Enzyme
This study determined the presence of Amp C beta lactamase producing Pseudomonas aeruginosa among the seventy four uropathogens studied using standard techniques. Results obtained revealed that the studied isolates show an alarming rate of resistance to the extended spectrum beta lactam antibiotics and the penicillin derivatives tested. The combination of piperacillin and tazobactam was however...
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Pseudomonas aeruginosa is an opportunistic pathogen which is naturally resistant to a large range of antibiotics like lots of Beta–Lactams (penicillins, cephalosporins and carbapenems) and may cause additional resistance after unsuccessful treatment. The understanding of beta-lactamase identification and detection in these bacteria is very valuable. In recent years a number of variety of new be...
متن کاملMultidrug-resistant Pseudomonas aeruginosa producing PER-1 extended-spectrum serine-beta-lactamase and VIM-2 metallo-beta-lactamase.
MA. The isolation of strains of rickettsiae of the spotted fever group in Israel and their differentiation from other members of the group by immunofluorescence methods. Scand J Infect Dis 1974;6:53-62. 7. Beati L, Finidori JP, Gilot B, Raoult D. Comparison of serologic typing, sodium dodecyl sulfate-polyacrylamide gel electrophore-sis protein analysis, and genetic restriction fragment length p...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1993
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.37.5.962